BioProcessing Bites Mini Web Series 2020

BioProcessing Bites

Spent Media Analysis At-Line, Anytime with the Rebel with 908 Devices, Novel Approach to Real-Time Biophysical Characterization with DRS Daylight Solutions, & Rapid Cycling Chromatography to Meet Future Demand in mAb Purification with Cytiva
11am EST / 8am PST / 4pm BST / 5pm CEST

Spent Media Analysis At-Line, Anytime with the Rebel
There is a need for advanced process analytic technologies that can monitor essential bioreactor nutrients and cellular metabolites alongside bioreactors in process development labs. Shown here is a new benchtop analyzer that enables wide (>30 analytes) and rapid analysis of cell media with just ten microliters of sample. The Rebel analyzer can run samples with only filtration and dilution, eliminating the need for labeling required from comparable approaches. This presentation will highlight the robustness of the platform along with several applications including its use for fresh and spent media analysis.

Novel Approach to Real-Time Biophysical Characterization
Are you interested in a PAT compatible tool that can characterize higher order structures, quantitate high titer proteins biologics and perform carbohydrate analysis? Process analytical technology (PAT) has quickly gained importance in biopharmaceutical industry for monitoring and controlling critical process parameters in raw materials and in-process products. Widely accepted PAT has now become a regulatory initiative to maintain the critical quality attributes (CQAs) to build quality into the final drug product.

Please join us for this free webinar to learn how mid-IR laser spectroscopy is enabling real-time biophysical characterization.

Rapid Cycling Chromatography to Meet Future Demand in mAb Purification
Fibro is a new protein A fiber chromatography format developed to complement traditional resin-based chromatography. The protein A fiber matrix has an open pore structure where mass transfer is governed by convective flow. This structure allows high mAb binding capacities at very short residence times, which reduces cycle times to minutes instead of the hours needed for resin-based chromatography.

These short cycle times enable high-throughput purification of mAbs and opportunities for significant time savings in process development. At a larger scale, the protein A fiber operated in a rapid cycling manner allows full utilization of the protein A lifetime during one batch as well as cost-effective single-use chromatography.

In this presentation we will show examples of how Fibro technology can help to optimize wash and elution buffers in downstream process development and reduce development times. We will also show how this scalable technology enhances productivity at process scale.

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